Endolysosomal trapping of therapeutics and endosomal escape strategies,Drug Discovery Today

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Endolysosomal trapping of therapeutics and endosomal escape strategies
Drug Discovery Today ( IF 6.5 ) Pub Date : 2024-06-26 , DOI: 10.1016/j.drudis.2024.104070
Aqeel Ahmad ₁ , Javed Masood Khan ₂ , Bilal Ahamad Paray ₃ , Khalid Rashid ₄ , Ashib Parvez ₅

Affiliation

Internalizing therapeutic molecules or genes into cells and safely delivering them to the target tissue where they can perform the intended tasks is one of the key characteristics of the smart gene/drug delivery vector. Despite much research in this field, endosomal escape continues to be a significant obstacle to the development of effective gene/drug delivery systems. In this review, we discuss in depth the several types of endocytic pathways involved in the endolysosomal trapping of therapeutic agents. In addition, we describe numerous mechanisms involved in nanoparticle endosomal escape. Furthermore, many other techniques are employed to increase endosomal escape to minimize entrapment of therapeutic compounds within endolysosomes, which have been reviewed at length in this study.

中文翻译：

内溶酶体捕获治疗和内体逃逸策略

将治疗分子或基因内化到细胞中并将它们安全地递送到可以执行预期任务的目标组织是智能基因/药物递送载体的关键特征之一。尽管在该领域进行了大量研究，内体逃逸仍然是开发有效基因/药物递送系统的重大障碍。在这篇综述中，我们深入讨论了参与治疗药物内溶酶体捕获的几种类型的内吞途径。此外，我们描述了涉及纳米颗粒内体逃逸的多种机制。此外，还采用了许多其他技术来增加内体逃逸，以最大程度地减少内溶酶体内治疗化合物的截留，这些技术已在本研究中进行了详细综述。

更新日期：2024-06-26

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