The SWI/SNF complex, also known as the BRG1/BRM-associated factor (BAF) complex, represents a critical regulator of chromatin remodeling mechanisms in mammals. It is alternatively referred to as mSWI/SNF and has been suggested to be imbalanced in human disease compared with human health. Three types of BAF assemblies associated with it have been described, including (1) canonical BAF (cBAF), (2) polybromo-associated BAF (PBAF), and (3) non-canonical BAF (ncBAF) complexes. Each of these BAF assemblies plays a role, either functional or dysfunctional, in governing gene expression patterns, cellular processes, epigenetic mechanisms, and biological processes. Recent evidence increasingly links the dysregulation of mSWI/SNF complexes to various human non-malignant lung chronic disorders and lung malignant diseases. This review aims to provide a comprehensive general state-of-the-art and a profound examination of the current understanding of mSWI/SNF assembly processes, as well as the structural and functional organization of mSWI/SNF complexes and their subunits. In addition, it explores their intricate functional connections with potentially dysregulated transcription factors, placing particular emphasis on molecular and cellular pathogenic processes in lung diseases. These processes are reflected in human epigenome aberrations that impact clinical and therapeutic levels, suggesting novel perspectives on the diagnosis and molecular therapies for human respiratory diseases.

中文翻译：

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哺乳动物 SWI/SNF 复合物组装的临床前证据：人类肺部疾病治疗的表观遗传学见解和临床前景


SWI/SNF 复合体，也称为 BRG1/BRM 相关因子 (BAF) 复合体，是哺乳动物染色质重塑机制的关键调节因子。它也被称为 mSWI/SNF，有人认为与人类健康相比，它在人类疾病中是不平衡的。与之相关的三种类型的 BAF 组装体已被描述，包括 (1) 典型 BAF (cBAF)、(2) 多溴相关 BAF (PBAF) 和 (3) 非典型 BAF (ncBAF) 复合物。每个 BAF 组件在控制基因表达模式、细胞过程、表观遗传机制和生物过程中发挥着功能性或功能性的作用。最近的证据越来越多地将 mSWI/SNF 复合物的失调与各种人类非恶性肺部慢性疾病和肺部恶性疾病联系起来。本综述旨在对 mSWI/SNF 组装过程以及 mSWI/SNF 复合体及其亚基的结构和功能组织的当前理解提供全面的最新技术和深入的研究。此外，它还探讨了它们与潜在失调的转录因子之间复杂的功能联系，特别强调肺部疾病的分子和细胞致病过程。这些过程反映在影响临床和治疗水平的人类表观基因组畸变中，为人类呼吸系统疾病的诊断和分子治疗提出了新的视角。