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Intravital Imaging of the Human Cornea Reveals the Differential Effects of Season on Innate and Adaptive Immune Cell Morphodynamics
Ophthalmology ( IF 13.1 ) Pub Date : 2024-05-03 , DOI: 10.1016/j.ophtha.2024.04.020
Mengliang Wu 1 , Xinyuan Zhang 2 , Senuri Karunaratne 2 , Ji-Hyun Lee 2 , Edwin R Lampugnani 3 , Kevin J Selva 4 , Amy W Chung 4 , Scott N Mueller 4 , Holly R Chinnery 2 , Laura E Downie 2
Affiliation  

Defining how the in vivo immune status of peripheral tissues is shaped by the external environment has remained a technical challenge. We recently developed Functional in vivo confocal microscopy (Fun-IVCM) for dynamic, longitudinal imaging of corneal immune cells in living humans. This study investigated the effect of seasonal-driven environmental factors on the morphodynamic features of human corneal immune cell subsets.

中文翻译:


人角膜的活体成像揭示了季节对先天免疫细胞形态动力学和适应性免疫细胞形态动力学的不同影响



定义外周组织的体内免疫状态如何受外部环境影响仍然是一项技术挑战。我们最近开发了功能性体内共聚焦显微镜 (Fun-IVCM),用于对活体人类的角膜免疫细胞进行动态纵向成像。本研究调查了季节性驱动的环境因素对人角膜免疫细胞亚群形态动力学特征的影响。
更新日期:2024-05-03
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