Detection of extranodal extension on histopathology in surgically treated head and neck squamous cell carcinoma indicates poor prognosis. However, there is no consensus on the diagnostic criteria, interpretation, and reporting of histology detected extranodal extension, which has contributed to conflicting evidence in the literature, and likely clinical inconsistency. The Head and Neck Cancer International Group conducted a three-round modified Delphi process with a group of 19 international pathology experts representing 15 national clinical research groups to generate consensus recommendations for histology detected extranodal extension diagnostic criteria. The expert panel strongly agreed on terminology and diagnostic features for histology detected extranodal extension and soft tissue metastasis. Moreover, the panel reached consensus on reporting of histology detected extranodal extension and on nodal sampling. These consensus recommendations, endorsed by 19 organisations representing 34 countries, are a crucial development towards standardised diagnosis and reporting of histology detected extranodal extension, and more accurate data collection and analysis.

中文翻译：

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头颈癌组织病理学检查中检测到的结外扩散的标准化定义和诊断标准：头颈癌国际小组共识建议


在手术治疗的头颈鳞状细胞癌中，组织病理学检测到结外延伸表明预后不良。然而，对于组织学检测到的结外扩散的诊断标准、解释和报告尚未达成共识，这导致了文献中相互矛盾的证据以及可能的临床不一致。头颈癌国际小组与代表 15 个国家临床研究小组的 19 名国际病理学专家组成的小组进行了三轮改良德尔菲法，以就组织学检测结外扩散诊断标准产生共识建议。专家小组对组织学检测结外扩散和软组织转移的术语和诊断特征达成了强烈一致。此外，专家组还就组织学检测结外扩展的报告和结节取样达成了共识。这些共识建议得到了代表 34 个国家的 19 个组织的认可，是对组织学检测到的结外扩展的标准化诊断和报告以及更准确的数据收集和分析的重要发展。