It was proposed that a reorganization of the relationships between cognitive functions occurs in dementia, a vision that surpasses the idea of a mere decline of specific domains. The complexity of cognitive structure, as assessed by neuropsychological tests, can be captured by exploratory graph analysis (EGA). EGA was applied to the neuropsychological assessment of people (humans) with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer's disease (AD; total N = 638). Both sexes were included. In AD, memory scores detach from the other cognitive functions, and memory subdomains reduce their reciprocal relation. SCD showed a pattern of segregated neuropsychological domains, and MCI showed a noisy and less stable pattern. Results suggest that AD drives a reorganization of cognitive functions toward a less-fractionated architecture compared with preclinical conditions. Cognitive functions show a reorganization that goes beyond the performance decline. Results also have clinical implications in test interpretations and usage.

有人提出，认知功能之间关系的重组发生在痴呆症中，这一愿景超越了仅仅特定领域下降的想法。通过神经心理学测试评估的认知结构的复杂性可以通过探索性图分析 （EGA） 来捕捉。EGA 应用于主观认知能力下降 （SCD） 、轻度认知障碍 （MCI） 和阿尔茨海默病 （AD;总 N = 638） 患者 （人类） 的神经心理学评估。男女均被包括在内。在 AD 中，记忆分数与其他认知功能分离，而记忆子域减少了它们的互惠关系。SCD 表现出分离的神经心理学域模式，MCI 表现出嘈杂且不太稳定的模式。结果表明，与临床前条件相比，AD 驱动认知功能向分级较少的结构重组。认知功能显示出超越性能下降的重组。结果在测试解释和使用方面也具有临床意义。