In this study, Allan Balmain and colleagues used a mouse model to monitor stem cell networks at single-cell resolution during skin carcinogenesis, revealing two cancer stem cell states, rapid cycling and plasticity, between which cells can transition to drive tumour initiation, progression and therapy resistance.

中文翻译：

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单细胞分辨率下的致癌作用


在这项研究中，Allan Balmain 及其同事使用小鼠模型在皮肤癌发生过程中以单细胞分辨率监测干细胞网络，揭示了两种癌症干细胞状态：快速循环和可塑性，细胞可以在这两种状态之间进行转变以驱动肿瘤的发生、进展和发展。治疗抵抗。