Study question Are elevated doses of follicle stimulating hormone (FSH) detrimental to oocyte maturation and the efficacy of ovarian stimulation in good responders? Summary answer Elevated FSH levels reduce the number of oocytes collected from good responders. Patients receiving lower total FSH doses had optimal and higher maturation rates. What is known already There is an inverse relationship between the dose of exogeneous follicle stimulating hormone (FSH) and the number of oocytes retrieved. This relationship is independent of patient age or health and implies that excessive FSH doses administered during artificial reproductive technologies (ART) may be detrimental to oocyte maturation. Study design, size, duration This three-year retrospective, multicenter study included 1,075 oocyte donor cycles performed in three IVF clinics between January 2020 and December 2023 with at least a six-month interval between each cycle. Donors were all considered good responders and divided according to the total dose of FSH received per cycle (n = 289 cycles with <1,700 IU FSH; 400 cycles with 1,700 to 2,900 IU FSH; and 386 cycles with >2,900 IU FSH). Participants/materials, setting, methods The mean oocyte donor age was between 26.13 and 27.45 years old. The mean BMI for all three groups was 21. The association between the total FSH dose and serum anti-Müllerian hormone (AMH) level, follicle-to-oocyte index (FOI), number of oocytes retrieved, and oocyte maturation was assessed using the Student’s t-test (parametric) or Mann-Whitney-U test (non-parametric). Main results and the role of chance There were no significant differences in the mean serum AMH levels (5.31 vs. 5.27 vs. 5.13 ng/mL, respectively) and FOI (81.1 vs. 80.2 vs. 81.5, respectively) of patients who received different total doses of FSH. However, the number of oocytes retrieved from each group was inversely related to the total dose of FSH received (24.4 vs. 22.9 vs. 21.01 oocytes, respectively; p < 0.05) Limitations, reasons for caution Full characterization of the oocytes and their developmental potential was outside the scope of this retrospective study. Wider implications of the findings Gaining a better understanding of the complex interplay of gonadotropins throughout folliculogenesis can help optimize ovarian stimulation protocols to maximize the number of mature and developmentally competent oocytes recovered for clinical use. Trial registration number non applicable

中文翻译：

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P-699 COS 期间高水平的总 FSH 不利于反应良好者的卵母细胞发育：一项为期三年的回顾性多中心研究的结果


研究问题 卵泡刺激素 (FSH) 剂量升高是否会损害卵母细胞的成熟以及卵巢刺激对良好反应者的功效？摘要答案 FSH 水平升高会减少从良好反应者中收集的卵母细胞数量。接受较低总 FSH 剂量的患者具有最佳且较高的成熟率。已知的信息 外源卵泡刺激素 (FSH) 的剂量与取出的卵母细胞数量之间存在反比关系。这种关系与患者年龄或健康状况无关，并且意味着在人工生殖技术 (ART) 期间施用过量的 FSH 剂量可能不利于卵母细胞的成熟。研究设计、规模、持续时间 这项为期三年的回顾性多中心研究包括 2020 年 1 月至 2023 年 12 月期间在三个 IVF 诊所进行的 1,075 个卵母细胞捐赠周期，每个周期之间至少间隔六个月。捐赠者均被认为是良好的反应者，并根据每个周期接受的 FSH 总剂量进行划分（n = 289 个周期，<1,700 IU FSH；400 个周期，1,700 至 2,900 IU FSH；386 个周期，>2,900 IU FSH）。参与者/材料、环境、方法 卵母细胞捐赠者的平均年龄在 26.13 岁至 27.45 岁之间。所有三组的平均 BMI 均为 21。使用学生 t 检验（参数）或 Mann-Whitney-U 检验（非参数）。主要结果和机会的作用 平均血清 AMH 水平（分别为 5.31 vs. 5.27 vs. 5.13 ng/mL）和 FOI（81.1 vs. 80.2 vs. 81）没有显着差异。分别为 5）接受不同 FSH 总剂量的患者。然而，从每组中取出的卵母细胞数量与接受的 FSH 总剂量成反比（分别为 24.4 与 22.9 与 21.01 卵母细胞；p < 0.05） 局限性、谨慎原因 卵母细胞及其发育潜力的全面表征不属于本回顾性研究的范围。研究结果的更广泛影响更好地了解促性腺激素在整个卵泡发生过程中复杂的相互作用可以帮助优化卵巢刺激方案，以最大限度地增加临床使用的成熟且具有发育能力的卵母细胞的数量。 试用注册号不适用