A photocatalytic method for the generation of the 1,1,1,3,3,3-hexafluoroisopropyl radical,Organic Chemistry Frontiers

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A photocatalytic method for the generation of the 1,1,1,3,3,3-hexafluoroisopropyl radical
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2024-07-03 , DOI: 10.1039/d4qo01023j
Sergey S. Lunkov ₁ , Vladislav S. Kostromitin _{1,

2} , Artem A. Zemtsov ₁ , Vitalij V. Levin ₁ , Alexander D. Dilman ₁

Affiliation

A reagent for the introduction of the 1,1,1,3,3,3-hexafluoroisopropyl group is described. The reagent was obtained on a multi-gram scale in one step from readily available hexafluoroisopropyl alcohol and pentafluoropyridine. Under photoredox conditions, the reagent undergoes facile cleavage of the C–O bond to generate the fluorinated alkyl radical, which can effectively add at C,C double bonds in a variety of atom and group transfer processes.

中文翻译：

一种光催化产生1,1,1,3,3,3-六氟异丙基自由基的方法

描述了用于引入1,1,1,3,3,3-六氟异丙基的试剂。该试剂是从容易获得的六氟异丙醇和五氟吡啶一步获得多克规模的。在光氧化还原条件下，该试剂容易裂解C-O键，生成氟化烷基自由基，可以在各种原子和基团转移过程中有效地加成在C，C双键上。

更新日期：2024-07-03

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