AimTo investigate the associations between oral health and depression, anxiety and their comorbidity in the UK Biobank cohort.Materials and MethodsOral health problems were self‐reported at baseline. Symptoms of depression and anxiety were assessed using the Mental Health Questionnaire (PHQ‐4) in a cross‐sectional study. In the cohort study, diagnoses of depression and anxiety disorders were based on hospital records. Logistic regression and Cox regression models were used to analyse the association between oral health and depression/anxiety.ResultsA total of 305,188 participants were included in the cross‐sectional study, and multivariate analysis showed that periodontal disease was associated with depression and/or anxiety (odds ratio [OR]: 1.79, 95% confidence interval [CI]: 1.73–1.86). In the prospective cohort study involving 264,706 participants, periodontal disease was significantly associated with an increased risk of depression and/or anxiety (hazard ratio [HR]: 1.14, 95% CI: 1.10–1.19), depression (HR: 1.19, 95% CI: 1.13–1.25) and anxiety (HR: 1.13, 95% CI: 1.07–1.19). Periodontal disease was also significantly associated with comorbid depression and anxiety (HR: 1.27, 95% CI: 1.16–1.38). Multiple mediation analysis using baseline inflammatory factors showed that white blood cell count and C‐reactive protein explained 3.07% and 3.15% of the association between periodontal disease and depression and anxiety, respectively. However, the results of longitudinal multiple mediation analysis of inflammatory factors at first follow‐up (N = 10,673) were not significant.ConclusionsPeriodontal disease was found to be consistently associated with an increased risk of depression, anxiety and their comorbidity.

中文翻译：

---

口腔健康与抑郁和焦虑之间的关联：来自英国生物样本库的横断面和前瞻性队列研究


目的调查英国生物样本库队列中口腔健康与抑郁、焦虑及其合并症之间的关联。材料和方法在基线时自我报告口腔健康问题。在一项横断面研究中，使用心理健康问卷 （PHQ-4） 评估抑郁和焦虑的症状。在队列研究中，抑郁症和焦虑症的诊断基于医院记录。采用 Logistic 回归和 Cox 回归模型分析口腔健康与抑郁/焦虑之间的关联。结果横断面研究共纳入 305,188 名参与者，多变量分析显示牙周病与抑郁和/或焦虑相关 （比值比 [OR]： 1.79,95% 置信区间 [CI]： 1.73-1.86）。在涉及 264,706 名参与者的前瞻性队列研究中，牙周病与抑郁和/或焦虑风险增加显著相关 （风险比 [HR]： 1.14,95% CI： 1.10–1.19）、抑郁 （HR： 1.19， 95% CI： 1.13–1.25） 和焦虑 （HR： 1.13， 95% CI： 1.07–1.19）。牙周病也与共病抑郁和焦虑显著相关 （HR： 1.27， 95% CI： 1.16–1.38）。使用基线炎症因子的多重中介分析显示，白细胞计数和 C 反应蛋白分别解释了牙周病与抑郁和焦虑之间关联的 3.07% 和 3.15%。然而，首次随访时炎症因子的纵向多重介导分析 （N = 10,673） 结果不显著。结论发现牙周病始终与抑郁、焦虑及其合并症的风险增加相关。