Synthesis of Chromone-3-phosphonates via Arbuzov-Type C−P Cross Coupling from o-Hydroxyphenyl Enaminones and Phosphites,Advanced Synthesis & Catalysis

当前位置： X-MOL 学术 › Adv. Synth. Catal. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis of Chromone-3-phosphonates via Arbuzov-Type C−P Cross Coupling from o-Hydroxyphenyl Enaminones and Phosphites
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2024-07-01 , DOI: 10.1002/adsc.202400587
Dingsheng Cao ₁ , Jie-Ping Wan ₁ , Yunyun Liu ₁

Affiliation

With an in situ C‐H iodination tactic, an applicable method for the synthesis of chromone‐3‐phosphonates has been developed with trialkyl/triaryl phosphites as the reaction partners of o‐hydroxyphenyl enaminones by palladium catalysis. The product formation consists of cascade C‐H iodination, chromone annulation, and Arbuzov‐type C‐P cross coupling as major transformations. In addition to providing an enaminone‐based synthetic method to chromone‐3‐phosphonates, the work is of advantage for the step economy by skipping the separate operation for preparing iodo‐functionalized chromone intermediate.

中文翻译：

邻羟基苯基烯胺酮和亚磷酸酯通过 Arbuzov 型 C−P 交叉偶联合成 3-色酮膦酸酯

采用原位C-H碘化策略，以亚磷酸三烷基/三芳基酯作为邻羟基苯基烯胺酮的反应伙伴，通过钯催化开发了一种合成色酮-3-膦酸酯的适用方法。产物形成包括级联C-H碘化、色酮环化和Arbuzov型C-P交叉偶联作为主要转化。除了提供一种基于烯胺酮的色酮-3-膦酸酯合成方法外，该工作还通过跳过制备碘官能化色酮中间体的单独操作而有利于步骤经济。

更新日期：2024-07-01

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南