We report here a practical and cost-effective method for the synthesis of CHF₂-containing benzimidazo- and indolo[2,1,a]-isoquinolin-6(5H)-ones through a visible light-mediated difluoromethylation/cyclization cascade. The method, which affords functionalized multifused N-heterocyclic scaffolds in moderate to high yields under mild reaction conditions, is also easily scalable using low-cost 3D printed photoflow reactors.

中文翻译：

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批量和流程中可见光介导的二氟甲基化/环化：含CHF2的苯并咪唑-和吲哚并[2,1-a]异喹啉-6(5H)-酮的可规模合成


我们在此报告了一种实用且经济有效的方法，通过可见光介导合成含有苯并咪唑和吲哚[2,1,a]-异喹啉-6(5H)-酮的CHF ₂ 二氟甲基化/环化级联。该方法在温和的反应条件下以中等到高产率提供功能化的多稠合N-杂环支架，并且可以使用低成本的3D打印光流反应器轻松扩展。