Self-assembling short peptide amphiphiles, crafted through a minimalistic approach, spontaneously generate well-ordered nanostructures, facilitating the creation of precise nanostructured biomaterials for diverse biomedical applications. The seamless integration of bioactive metal ions and nanoparticles endows them with the potential to serve as pioneering materials in combating bacterial infections. Nanomanipulation of these molecules’ binary structures enables effective penetration of membranes, forming structured nanoarchitectures with antibacterial properties. Through a comprehensive exploration, we attempt to reveal the innovative potential of short peptide amphiphiles, particularly in conjugation with metal cations and nanoparticles, offering insights for future research trajectories.

中文翻译：

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自组装短肽两亲物作为多功能递送剂：抗菌研究的新前沿


通过极简方法制作的自组装短肽两亲物可自发生成有序的纳米结构，有助于为各种生物医学应用创建精确的纳米结构生物材料。生物活性金属离子和纳米颗粒的无缝结合赋予它们作为对抗细菌感染的先锋材料的潜力。对这些分子的二元结构进行纳米操作可以有效穿透膜，形成具有抗菌特性的结构化纳米结构。通过全面的探索，我们试图揭示短肽两亲物的创新潜力，特别是在与金属阳离子和纳米颗粒的结合方面，为未来的研究轨迹提供见解。