Burns are an underestimated serious injury negatively impacting survivors physically, psychologically and economically, and thus are a considerable public health burden. Despite significant advancements in burn treatment, many burns still do not heal or develop serious complications/sequelae. The nucleotide-binding oligomerization domain-like receptors (NLRs) family pyrin domain-containing 3 (NLRP3) inflammasome is a critical regulator of wound healing, including burn wound healing. A better understanding of the pathophysiological mechanism underlying the healing of burn wounds may help find optimal therapeutic targets to promote the healing of burn wounds, reduce complications/sequelae following burn, and maximize the restoration of structure and function of burn skin. This review aimed to summarize current understanding of the roles and regulatory mechanisms of the NLRP3 inflammasome in burn wound healing, as well as the preclinical studies of the involvement of NLRP3 inhibitors in burn treatment, highlighting the potential application of NLRP3-targeted therapy in burn wounds.

中文翻译：

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烧伤中的 NLRP3 炎症小体：一个新的潜在治疗靶点


烧伤是一种被低估的严重伤害，会对幸存者的身体、心理和经济产生负面影响，因此是相当大的公共卫生负担。尽管烧伤治疗取得了重大进展，但许多烧伤仍然无法治愈或出现严重的并发症/后遗症。核苷酸结合寡聚化结构域样受体 (NLR) 家族含热蛋白结构域 3 (NLRP3) 炎性体是伤口愈合（包括烧伤伤口愈合）的关键调节因子。更好地了解烧伤创面愈合的病理生理机制，有助于寻找最佳治疗靶点，促进烧伤创面愈合，减少烧伤后并发症/后遗症，最大限度恢复烧伤皮肤的结构和功能。本文旨在总结目前对NLRP3炎症小体在烧伤创面愈合中的作用和调控机制的认识，以及NLRP3抑制剂参与烧伤治疗的临床前研究，强调NLRP3靶向治疗在烧伤创面中的潜在应用。