Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification,Cell Host & Microbe

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Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2024-07-02 , DOI: 10.1016/j.chom.2024.06.008
Haiyuan Shen ₁ , Liangliang Zhou ₁ , Hao Zhang ₁ , Yuanru Yang ₂ , Ling Jiang ₃ , Dongqing Wu ₁ , Hang Shu ₁ , Hejiao Zhang ₄ , Linxi Xie ₅ , Kaichen Zhou ₆ , Chen Cheng ₇ , Lei Yang ₅ , Jiali Jiang ₅ , Siya Wang ₈ , Yiran Han ₉ , Jiayi Zhu ₉ , Long Xu ₅ , Zhihua Liu ₆ , Hua Wang ₁ , Shi Yin ₈

Affiliation

Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, China.
Department of Blood Transfusion, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Department of Nephropathy, The First Affiliated Hospital, Anhui Medical University, Hefei 230022, China.
Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
School of Basic Medical Science, Anhui Medical University, Hefei 230032, China.
Institute for Immunology, School of Basic Medical Science, Tsinghua University, Beijing 100084, China.
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, China; School of Basic Medical Science, Anhui Medical University, Hefei 230032, China.
Department of Geriatrics, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230002, China; Anhui Key Laboratory of Geriatric Immunology and Nutrition Therapy, Hefei 230027, China.
Innovation and Entrepreneurship Laboratory for College Students, Anhui Medical University, Hefei 230032, China.

The gut microbiota and diet-induced changes in microbiome composition have been linked to various liver diseases, although the specific microbes and mechanisms remain understudied. Alcohol-related liver disease (ALD) is one such disease with limited therapeutic options due to its complex pathogenesis. We demonstrate that a diet rich in soluble dietary fiber increases the abundance of () and alleviates alcohol-induced liver injury in mice. treatment alone ameliorates liver injury through a bile salt hydrolase that generates unconjugated bile acids to activate intestinal farnesoid X receptor (FXR) and its downstream target, fibroblast growth factor-15 (FGF15). FGF15 promotes hepatocyte expression of ornithine aminotransferase (OAT), which facilitates the metabolism of accumulated ornithine in the liver into glutamate, thereby providing sufficient glutamate for ammonia detoxification via the glutamine synthesis pathway. Collectively, these findings uncover a potential therapeutic strategy for ALD involving dietary fiber supplementation and .

中文翻译：

膳食纤维通过产酸拟杆菌和随后的氨解毒减轻酒精性肝损伤

肠道微生物群和饮食引起的微生物组组成的变化与各种肝脏疾病有关，尽管具体的微生物和机制仍未得到充分研究。酒精相关性肝病（ALD）就是这样一种疾病，由于其复杂的发病机制，治疗选择有限。我们证明，富含可溶性膳食纤维的饮食会增加 () 的丰度并减轻小鼠酒精引起的肝损伤。单独治疗可通过胆汁盐水解酶改善肝损伤，该酶产生未结合的胆汁酸，激活肠道法尼醇 X 受体 (FXR) 及其下游靶标成纤维细胞生长因子 15 (FGF15)。 FGF15促进肝细胞表达鸟氨酸转氨酶（OAT），促进肝脏中积累的鸟氨酸代谢为谷氨酸，从而通过谷氨酰胺合成途径为氨解毒提供足够的谷氨酸。总的来说，这些发现揭示了 ALD 的潜在治疗策略，涉及补充膳食纤维和。

更新日期：2024-07-02

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