The heart is the most metabolically active organ in the human body, and cardiac metabolism has been studied for decades. However, the bulk of studies have focused on animal models. The objective of this review is to summarize specifically what is known about cardiac metabolism in humans. Techniques available to study human cardiac metabolism are first discussed, followed by a review of human cardiac metabolism in health and in heart failure. Mechanistic insights, where available, are reviewed, and the evidence for the contribution of metabolic insufficiency to heart failure, as well as past and current attempts at metabolism-based therapies, is also discussed.

中文翻译：

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人体心脏代谢

心脏是人体代谢最活跃的器官，心脏代谢的研究已有数十年历史。然而，大部分研究都集中在动物模型上。本综述的目的是具体总结有关人类心脏代谢的已知信息。首先讨论可用于研究人类心脏代谢的技术，然后回顾健康和心力衰竭情况下的人类心脏代谢。回顾了可用的机制见解，并讨论了代谢不足导致心力衰竭的证据，以及过去和当前基于代谢的治疗的尝试。