Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease–related cognitive decline: Multi-site validation in the MarkVCID Consortium,Alzheimer's & Dementia

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Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease–related cognitive decline: Multi-site validation in the MarkVCID Consortium
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-07-01 , DOI: 10.1002/alz.13888
Peiying Liu _{1,

2} , Zixuan Lin ₁ , Kaisha Hazel ₁ , George Pottanat ₁ , Cuimei Xu ₁ , Dengrong Jiang ₁ , Jay J Pillai _{1,

3} , Emma Lucke ₁ , Christopher E Bauer ₄ , Brian T Gold ₄ , Steven M Greenberg ₅ , Karl G Helmer ₆ , Kay Jann ₇ , Gregory Jicha ₈ , Joel Kramer ₉ , Pauline Maillard ₁₀ , Rachel M Mulavelil ₁₁ , Pavel Rodriguez ₁₁ , Claudia L Satizabal ₁₁ , Kristin Schwab ₅ , Sudha Seshadri ₁₁ , Herpreet Singh ₆ , Ángel G Velarde Dediós ₁₁ , Danny J J Wang ₇ , Rita R Kalyani ₁₂ , Abhay Moghekar ₁₃ , Paul B Rosenberg ₁₄ , Sevil Yasar ₁₂ , Marilyn Albert ₁₃ , Hanzhang Lu _{1,

15,

16}

Affiliation

Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Department of Division of Neuroradiology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.
Department of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, Massachusetts, USA.
Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Laboratory of Functional MRI Technology, Keck School of Medicine, Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, California, USA.
Department of Neurology, University of Kentucky, Lexington, Kentucky, USA.
Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Department of Neurology, University of California, Davis, Sacramento, California, USA.
Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, Texas, USA.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, USA.
F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.

Vascular contributions to cognitive impairment and dementia (VCID) represent a major factor in cognitive decline in older adults. The present study examined the relationship between cerebrovascular reactivity (CVR) measured by magnetic resonance imaging (MRI) and cognitive function in a multi-site study, using a predefined hypothesis.

中文翻译：

脑血管反应性 MRI 作为脑小血管疾病相关认知能力下降的生物标志物：MarkVCID 联盟的多中心验证

血管对认知障碍和痴呆（VCID）的影响是老年人认知能力下降的一个主要因素。本研究使用预先定义的假设，在多中心研究中检查了磁共振成像（MRI）测量的脑血管反应性（CVR）与认知功能之间的关系。

更新日期：2024-07-01

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