A copper‐catalyzed annulation of enaminones with maleimides was developed to synthesize various pyrrolo[3,4‐e] isoindoles. In this strategy, 2‐aminopyridine served as a traceless directing group, and target products were obtained in 54‐72% yields. Moreover, a plausible mechanism for this reaction was proposed based on several control experiments, deuterium exchange experiments, and previous reports.

中文翻译：

---

使用无痕导向基团策略铜(II)催化烯胺酮与马来酰亚胺的[2+2+2]环化


开发了铜催化的烯胺与马来酰亚胺的环化来合成各种吡咯并[3,4-e]异吲哚。在该策略中，2-氨基吡啶作为无痕导向基团，以54-72%的产率获得了目标产物。此外，基于一些对照实验、氘交换实验和之前的报告，提出了该反应的合理机制。