Nickel-Catalyzed Regio- and Stereoselective Reductive Alkylative Cyclization of 1,6-Enynes with Alkyl Bromides,Advanced Synthesis & Catalysis

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Nickel-Catalyzed Regio- and Stereoselective Reductive Alkylative Cyclization of 1,6-Enynes with Alkyl Bromides
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2024-07-01 , DOI: 10.1002/adsc.202400575
Yunxin Xing ₁ , Zhu Tian ₁ , Kun Shen ₁

Affiliation

A nickel-catalyzed reductive alkylative cyclization of 1,6-enynes with alkyl bromides has been developed. This transformation avoids the use of stoichiometric organometallic reagents and introduces alkyl groups regio- and stereoselectively into the products. This method provides a platform for the synthesis of carbo- and heterocycles that are widely found in many natural products and biologically active molecules.

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