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Cryo-EM structures of γ-TuRC reveal molecular insights into microtubule nucleation
Nature Structural & Molecular Biology ( IF 12.5 ) Pub Date : 2024-07-02 , DOI: 10.1038/s41594-024-01345-z
Léa Mammri 1 , Paul T Conduit 1
Affiliation  

Microtubules within cells often have 13 protofilaments but are nucleated by multi-protein y-TuRCs complexes that display 14 γ-tubulin molecules. High-resolution cryo-EM structures of γ-TuRCs after nucleation show that these γ-TuRCs ‘close’ during nucleation to display only 13 γ-tubulin molecules for protofilament assembly.

中文翻译:


γ-TuRC 的冷冻电镜结构揭示了微管成核的分子见解



细胞内的微管通常有 13 个原丝,但由显示 14 个 γ-微管蛋白分子的多蛋白 y-TuRC 复合物成核。成核后 γ-TuRC 的高分辨率冷冻电镜结构表明,这些 γ-TuRC 在成核过程中“闭合”,仅显示 13 个用于原丝组装的 γ-微管蛋白分子。
更新日期:2024-07-02
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