When President Bill Clinton and Francis Collins, then the director of the National Human Genome Research Institute, celebrated the near completion of the human genome sequence at the White House in the summer of 2000, it is unlikely that they or anyone else could have predicted the blossoming of meta-omics in the following two decades and their applications in modern human microbiome and environmental microbiome research. This transformation was enabled by the development of high-throughput sequencing technologies and sophisticated computational biology tools and bioinformatics software packages. Today, environmental meta-omics has undoubtedly revolutionized our understanding of ocean ecosystems, providing the genetic blueprint of oceanic microscopic organisms. In this review, I discuss the importance of functional genomics in future marine microbiome research and advocate a position for a gene-centric, bottom-up approach in modern oceanography. I propose that a synthesis of multidimensional approaches is required for a better understanding of the true functionality of the marine microbiome.

中文翻译：

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超越元组学：未来海洋微生物组研究中的功能基因组学


2000 年夏天，当比尔·克林顿总统和时任国家人类基因组研究所所长的弗朗西斯·柯林斯在白宫庆祝人类基因组序列即将完成时，他们或其他任何人都不太可能预见到元组学在接下来的二十年里蓬勃发展，以及它们在现代人类微生物组和环境微生物组研究中的应用。这种转变是通过高通量测序技术以及复杂的计算生物学工具和生物信息学软件包的发展实现的。今天，环境元组学无疑彻底改变了我们对海洋生态系统的理解，提供了海洋微观生物的遗传蓝图。在这篇综述中，我讨论了功能基因组学在未来海洋微生物组研究中的重要性，并倡导在现代海洋学中采用以基因为中心、自下而上的方法。我提出需要综合多维方法，以更好地了解海洋微生物组的真正功能。