Comprehensive dissection of the transcriptional basis of basal-like differentiation of pancreatic ductal adenocarcinoma (PDAC) revealed MED12 as a core regulator of this abnormal identity. Mechanistic studies demonstrate that MED12 cooperates with the basal-like master regulator transcription factor ΔNp63 by bridging it with the critical Mediator co-activator complex.

中文翻译：

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ΔNp63–MED12 轴驱动胰腺癌的基底样身份


对胰腺导管腺癌 (PDAC) 基底样分化的转录基础的全面剖析揭示了 MED12 是这种异常身份的核心调节因子。机制研究表明，MED12 通过将其与关键的介体共激活剂复合物桥接来与基底样主调节转录因子 ΔNp63 合作。