The importance of subcellular mRNA localization is well established, but the underlying mechanisms mostly remain an enigma. Early studies suggested that specific mRNA sequences recruit RNA-binding proteins (RBPs) to regulate mRNA localization. However, despite the observation of thousands of localized mRNAs, only a handful of these sequences and RBPs have been identified. This suggests the existence of alternative, and possibly predominant, mechanisms for mRNA localization. Here I re-examine currently described mRNA localization mechanisms and explore alternative models that could account for its widespread occurrence.

中文翻译：

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对广泛 RNA 定位基础的机制见解

亚细胞 mRNA 定位的重要性已广为人知，但其潜在机制仍然是个谜。早期研究表明，特定的 mRNA 序列招募 RNA 结合蛋白 (RBP) 来调节 mRNA 定位。然而，尽管观察到了数千个局部 mRNA，但仅鉴定了其中少数序列和 RBP。这表明存在替代的、可能是主要的 mRNA 定位机制。在这里，我重新审视目前描述的 mRNA 定位机制，并探索可以解释其广泛发生的替代模型。