In sepsis treatment, antibiotics are crucial, but overuse risks development of antibiotic resistance. Recent guidelines recommended the use of procalcitonin to guide antibiotic cessation, but solid evidence is insufficient. Recently, concerns were raised that this strategy would increase recurrence. Additionally, optimal protocol or difference from the commonly used C-reactive protein (CRP) are uncertain. We aimed to compare the effectiveness and safety of procalcitonin- or CRP-guided antibiotic cessation strategies with standard of care in sepsis.

中文翻译：

---

降钙素原或 C 反应蛋白引导的脓毒症危重成人停用抗生素的益处和危害：系统评价和网络荟萃分析。


在脓毒症治疗中，抗生素至关重要，但过度使用可能会导致抗生素耐药性的产生。最近的指南建议使用降钙素原来指导停用抗生素，但确凿的证据不足。最近，有人担心这种策略会增加复发率。此外，最佳方案或与常用 C 反应蛋白 (CRP) 的差异尚不确定。我们的目的是将降钙素原或 CRP 指导的抗生素戒断策略与脓毒症护理标准的有效性和安全性进行比较。