To solve the difficulty of natural healing in patients with severe bone defects, and the challenges of insufficient autologous bone graft material and large incisions in conventional surgery, we were designed an intelligent co-regulated hydrogel system with NIR response. The goal is to be able to prevent inflammation and bacterial adhesion, thereby promoting repair and development of the bone defect area. The hydrogel system consisted of hyaluronic acid, carboxymethyl chitosan and Pht-loaded PDA-encapsulated ZIF-8 NPs (Pht@ZIF-8@PDA) by Schiff base reaction. Compared to high-temperature photothermal therapy (PTT), which destroyed surrounding healthy cells, the present study was based on a new strategy of mild photothermal therapy (42.5 ± 1.2 °C) and leaded to a better promotion of osteogenesis. NIR activated the photothermal properties of PDA in scaffolds, intelligently released Pht and Zn, inhibited and (inhibition rate ≥ 96 %), and promoted bone regeneration in the rat model. Meanwhile, it could promote bone regeneration by upregulating osteogenic factors and stimulating the expression of proteins related to BMP/SMAD signaling pathway. The research highlights the potential applications of synergistically modulated hydrogels, which opens up a new application path for this material in bone tissue engineering, regenerative medicine, and other related fields.

中文翻译：

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具有光热效应的智能控释水凝胶用于治疗骨缺损


为了解决严重骨缺损患者自然愈合的困难，以及传统手术中自体骨移植材料不足和切口大的挑战，我们设计了一种具有近红外响应的智能共调节水凝胶系统。目标是能够防止炎症和细菌粘附，从而促进骨缺损区域的修复和发展。该水凝胶系统由透明质酸、羧甲基壳聚糖和通过席夫碱反应制备的负载 Pht 的 PDA 封装的 ZIF-8 纳米粒子 (Pht@ZIF-8@PDA) 组成。与破坏周围健康细胞的高温光热疗法（PTT）相比，本研究基于温和光热疗法（42.5±1.2°C）的新策略，并能更好地促进成骨。 NIR激活支架内PDA的光热特性，智能释放Pht和Zn，抑制和（抑制率≥96%），促进大鼠模型骨再生。同时，它可以通过上调成骨因子、刺激BMP/SMAD信号通路相关蛋白的表达来促进骨再生。该研究凸显了协同调制水凝胶的潜在应用前景，为该材料在骨组织工程、再生医学等相关领域开辟了新的应用路径。