Solution Gated Graphene Field-Effect Transistors (SGGT) are eagerly anticipated as an amplification platform for fabricating advanced ultra-sensitive sensors, allowing significant modulation of the drain current with minimal gate voltage. However, few studies have focused on light-matter interplay gating control for SGGT. Herein, this challenge is addressed by creating an innovative photoelectrochemical solution-gated graphene field-effect transistor (PEC-SGGT) functionalized with enzyme cascade reactions (ECR) for Organophosphorus (OPs) detection. The ECR system, consisting of acetylcholinesterase (AChE) and CuBTC nanomimetic enzymes, selectively recognizes OPs and forms o-phenylenediamine (oPD) oligomers sediment on the PEC electrode, with layer thickness related to the OPs concentration, demonstrating time-integrated amplification. Under light stimulation, the additional photovoltage generated on the PEC gate electrode is influenced by the oPD oligomers sediment layer, creating a differentiated voltage distribution along the gate path. PEC-SGGT, inherently equipped with built-in amplification circuits, sensitively captures gate voltage changes and delivers output with an impressive thousandfold current gain. The seamless integration of these three amplification modes in this advanced sensor allows a good linear range and highly sensitive detection of OPs, with a detection limit as low as 0.05 pm. This work provides a proof-of-concept for the feasibility of light-assisted functionalized gate-controlled PEC-SGGT for small molecule detection.

中文翻译：

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通过酶级联反应功能化的光电化学溶液门控石墨烯场效应晶体管用于有机磷检测


解决方案 门控石墨烯场效应晶体管 (SGGT) 被期待作为制造先进超灵敏传感器的放大平台，允许以最小的栅极电压对漏极电流进行显着调制。然而，很少有研究关注 SGGT 的光-物质相互作用门控控制。在此，通过创建一种创新的光电化学溶液门控石墨烯场效应晶体管（PEC-SGGT）来解决这一挑战，该晶体管具有用于有机磷（OP）检测的酶级联反应（ECR）功能。 ECR 系统由乙酰胆碱酯酶 (AChE) 和 CuBTC 纳米模拟酶组成，选择性识别 OP 并在 PEC 电极上形成邻苯二胺 (oPD) 低聚物沉积物，层厚度与 OP 浓度相关，表现出时间积分放大。在光刺激下，PEC 栅电极上产生的额外光电压受到 oPD 低聚物沉积层的影响，沿栅极路径产生差异化的电压分布。 PEC-SGGT本身就配备了内置放大电路，可以灵敏地捕捉栅极电压变化，并以令人印象深刻的千倍电流增益提供输出。这种先进传感器中这三种放大模式的无缝集成可实现良好的线性范围和高灵敏度的 OP 检测，检测限低至 0.05 pm。这项工作为光辅助功能化门控 PEC-SGGT 用于小分子检测的可行性提供了概念验证。