A straightforward method for the synthesis of difluoroalkylated bicyclopentanes (BCPs) from [1.1.1]propellane (TCP) through a stepwise procedure has been developed. This process involves nucleophilic addition of organozinc or ArMgBr rea-gents to TCP, followed by reaction with difluorocarbene to generate BCP substituted difluoroalkylzinc species, which subsequently couple with electrophiles, including allyl/propargyl bromides, (hetero)aryl disulfides, and proton, to provide a wide range of difluoroalkylated BCPs that otherwise are difficult to access through conventional methods. The transformations of the resulting products demonstrate the synthetic utility of this modular synthesis.

中文翻译：

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二氟卡宾能够模块化合成二氟烷基化双环戊烷


已经开发出一种通过分步程序从[1.1.1]丙烷（TCP）合成二氟烷基化双环戊烷（BCP）的简单方法。该过程涉及将有机锌或 ArMgBr 试剂亲核加成到 TCP 上，然后与二氟卡宾反应生成 BCP 取代的二氟烷基锌物质，随后与亲电试剂（包括烯丙基/炔丙基溴、（杂）芳基二硫化物和质子）偶联，提供多种二氟烷基化 BCP，否则很难通过传统方法获得。所得产品的转化证明了这种模块化合成的综合效用。