The hydrocyanation of alkenes can be considered a straightforward methodology that gives access to different functionalized organic chemistry entities. This is due to nitrile's high versatility, which can easily undergo further transformations. However, this process has traditionally employed hazardous hydrogen cyanide as the hydrocyanation agent. Therefore, in the last decades, different protocols have been developed to accomplish this key organic transformation without needing to handle HCN. In this review, we aim to gather the most recent works published in the last couple of decades regarding the hydrocyanation of non‐activated olefins in the absence of gaseous hydrogen cyanide as nitrile source. In addition, special attention has been paid to the reaction mechanism working in each case.

中文翻译：

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不处理 HCN 的非活化烯烃的氢氰化


烯烃的氢氰化可以被认为是一种简单的方法，可以得到不同的官能化有机化学实体。这是由于丁腈具有很高的多功能性，可以很容易地进行进一步的转化。然而，该工艺传统上使用危险的氰化氢作为氢氰化剂。因此，在过去的几十年里，人们开发了不同的协议来完成这一关键的有机转变，而无需处理 HCN。在这篇综述中，我们的目标是收集过去几十年发表的关于在没有气态氰化氢作为腈源的情况下非活化烯烃的氢氰化的最新著作。此外，还特别关注了每种情况下的反应机理。