Bacterial infections, especially those from drug‐resistant strains, pose a significant threat to healing diabetic skin injuries, with current treatments being intricated and often unsatisfactory. Inspired by octopuses, a biomimetic material using α‐cyclodextrin (α‐CD) and polyethylene glycol (PEG) assembled with graphene oxide end‐capped polyrotaxanes (GO‐PR) is developed, where α‐CD mimics the flexible tentacles of an octopus. Further, α‐CD is cationically modified with polyethyleneimine (PEI) to resemble octopus suction cups, creating GO‐PRP, which effectively captures and adheres to bacteria. Importantly, to emulate an octopus's ink defense, GO‐PRP is used as a carrier for nitric oxide (NO), resulting in GO‐PRP/NONOate. Utilizing the photothermal conversion of GO, near‐infrared light exposure triggers rapid heating and NO release, providing efficient antibacterial activity and biofilm dispersion, significantly reducing inflammation in diabetic skin injuries in type I rats. During wound healing, sustained NO release promotes vascular endothelial growth factor production and blood vessel regeneration, enhancing collagen formation and shortening the healing time for diabetic skin infections. Thus, octopus‐inspired GO‐PRP/NONOate emerges as a novel biomaterial for treating drug‐resistant bacterial infections in diabetic wounds in the biomedical field.

中文翻译：

---

章鱼启发的自适应分子运动在糖尿病伤口修复中的协同光热和一氧化氮抗菌疗法


细菌感染，尤其是耐药菌株的细菌感染，对糖尿病皮肤损伤的愈合构成重大威胁，目前的治疗方法复杂且往往不令人满意。受章鱼的启发，开发了一种使用α-环糊精（α-CD）和聚乙二醇（PEG）与氧化石墨烯封端的聚轮烷（GO-PR）组装的仿生材料，其中α-CD模仿章鱼的柔性触手。此外，α-CD 用聚乙烯亚胺 (PEI) 进行阳离子修饰，类似于章鱼吸盘，形成 GO-PRP，可有效捕获并粘附细菌。重要的是，为了模拟章鱼的墨汁防御，GO-PRP 被用作一氧化氮 (NO) 的载体，从而产生 GO-PRP/NONOate。利用GO的光热转换，近红外光照射触发快速加热和NO释放，提供高效的抗菌活性和生物膜分散，显着减少I型大鼠糖尿病皮肤损伤的炎症。在伤口愈合过程中，持续的一氧化氮释放可促进血管内皮生长因子的产生和血管再生，增强胶原蛋白的形成并缩短糖尿病皮肤感染的愈合时间。因此，受章鱼启发的 GO-PRP/NONOate 成为生物医学领域治疗糖尿病伤口耐药细菌感染的新型生物材料。