Postoperative adhesions complicate the majority of surgical procedures, imposing an excess medical burden. The segregation of injured tissue from healthy tissue is considered the optimal therapeutic strategy. However, achieving hemostasis while preventing adhesions in the immediate postoperative setting continues to pose a significant challenge. This paper presents the in situ formation of an asymmetrically adhesive hydrogel barrier via a sprayable dry powder (SDP) that enables interfacial water‐induced, ultra‐rapid gelation. Owing to SDP hydrophilicity and the interstitial spaces between particles, it can rapidly and efficiently absorb interfacial water, thereby facilitating smooth cross‐linking between material functional groups and tissue functional groups. In addition, SDP becomes less adhesive after gelation as a layer of interfacial water forms on the surface of the SDP hydrogel, enhancing its anti‐adhesion properties. Animal experiment outcomes demonstrate that SDP exhibits significant asymmetric adhesive properties before and after gelation, successfully preventing postoperative adhesions. As a result, SDP heralds a novel approach to the development of adhesives that can simultaneously mitigate adhesions and promptly arrest bleeding.

中文翻译：

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湿组织界面水引发可喷雾干粉的超快原位凝胶化，用于术后防粘连


术后粘连使大多数外科手术变得复杂，造成了额外的医疗负担。将受伤组织与健康组织分离被认为是最佳治疗策略。然而，在术后立即实现止血的同时防止粘连仍然构成重大挑战。本文介绍了通过可喷雾干粉（SDP）原位形成不对称粘合水凝胶屏障，从而实现界面水诱导的超快速凝胶化。由于SDP的亲水性和颗粒之间的间隙，它可以快速有效地吸收界面水，从而促进材料官能团和组织官能团之间顺利交联。此外，由于SDP水凝胶表面形成一层界面水，凝胶化后SDP的粘合性降低，增强了其抗粘连性能。动物实验结果表明，SDP在凝胶化前后表现出显着的不对称粘合特性，成功防止术后粘连。因此，SDP 预示着一种开发粘合剂的新方法，可以同时减轻粘连并迅速止血。