Prussian blue-decorated indocyanine green-loaded mesoporous silica nanohybrid for synergistic photothermal-photodynamic-chemodynamic therapy against methicillin-resistant Staphylococcus aureus,Colloids and Surfaces B: Biointerfaces

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Prussian blue-decorated indocyanine green-loaded mesoporous silica nanohybrid for synergistic photothermal-photodynamic-chemodynamic therapy against methicillin-resistant Staphylococcus aureus
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2024-06-27 , DOI: 10.1016/j.colsurfb.2024.114065
Chenyang Qi ₁ , Guitao Tan ₁ , Haonan Hu ₁ , Yipin Zhang ₁ , Jie Chen ₁ , Qinqin Zhang ₁ , Jing Tu ₁

Affiliation

Nanomaterial-based synergistic antibacterial agents are considered as promising tools to combat infections caused by antibiotic-resistant bacteria. Herein, multifunctional mesoporous silica nanoparticle (MSN)-based nanocomposites were fabricated for synergistic photothermal/photodynamic/chemodynamic therapy against methicillin-resistant (MRSA). MSN loaded with indocyanine green (ICG) as a core, while Prussian blue (PB) nanostructure was decorated on MSN surface growth method to form a core-shell nanohybrid (MSN-ICG@PB). Upon a near infrared (NIR) laser excitation, MSN-ICG@PB (200 μg mL) exhibited highly efficient singlet oxygen (O) generation and hyperthermia effect (48.7℃). In the presence of exogenous HO, PB with peroxidase-like activity promoted the generation of toxic hydroxyl radicals (•OH) to achieve chemodynamic therapy (CDT). PTT can greatly increase the permeability of bacterial lipid membrane, facilitating the generated O and •OH to kill bacteria more efficiently. Under NIR irradiation and exogenous HO, MSN-ICG@PB (200 μg mL) with good biocompatibility exhibited a synergistic antibacterial effect against MRSA with high bacterial killing efficiency (>98 %). Moreover, due to the synergistic bactericidal mechanism, MSN-ICG@PB with satisfactory biosafety makes it a promising antimicrobial agent to fight against MRSA.

中文翻译：

普鲁士蓝修饰吲哚菁绿介孔二氧化硅纳米杂化物用于协同光热-光动力-化学动力学治疗耐甲氧西林金黄色葡萄球菌

基于纳米材料的协同抗菌剂被认为是对抗抗生素耐药细菌引起的感染的有前途的工具。在此，制备了基于多功能介孔二氧化硅纳米颗粒（MSN）的纳米复合材料，用于针对耐甲氧西林（MRSA）的协同光热/光动力/化学动力疗法。 MSN以吲哚菁绿（ICG）为核心，通过MSN表面生长方法修饰普鲁士蓝（PB）纳米结构，形成核壳纳米杂化物（MSN-ICG@PB）。在近红外（NIR）激光激发下，MSN-ICG@PB（200 μg mL）表现出高效的单线态氧（O）生成和热效应（48.7℃）。在外源性H2O存在下，具有类过氧化物酶活性的PB促进有毒羟基自由基（•OH）的产生，从而实现化学动力学治疗（CDT）。 PTT可以大大增加细菌脂膜的通透性，有利于产生O和·OH，更有效地杀灭细菌。在近红外辐射和外源H2O照射下，具有良好生物相容性的MSN-ICG@PB (200 μg mL)对MRSA表现出协同抗菌作用，且杀菌效率高(>98%)。此外，由于协同杀菌机制，MSN-ICG@PB具有令人满意的生物安全性，使其成为对抗MRSA的有前途的抗菌剂。

更新日期：2024-06-27

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