Sonoporation is a non-invasive method that uses ultrasound for drug and gene delivery for therapeutic purposes. Here, both Finite Element Method (FEM) and Lattice Boltzmann Method (LBM) are applied to study the interaction physics of microbubble oscillation and collapse near flexible tissue. After validating the Finite Element Method with the nonlinear excited lipid-coated microbubble as well as the Lattice Boltzmann Method with experimental results, we have studied the behavior of a three-dimensional compressible microbubble in the vicinity of tissue. In the FEM phase, the oscillation microbubble with a lipid shell interacts with the boundary. The range of pressure and ultrasound frequency have been considered in the field of therapeutic applications of sonoporation. The viscoelastic and interfacial tension as the coating properties of the microbubble shell have been investigated. The presence of an elastic boundary increases the resonance frequency of the microbubble compared to that of a free microbubble. The increase in pressure leads to an expansion in the range of the microbubble’s motion, the velocity induced in the fluid, and the shear stress on the boundary walls of tissue. An enhancement in the surface tension of the microbubble can influence fluid flow and reduce the shear stress on the boundary. The multi-pseudo-potential interaction LBM is used to reduce thermodynamic inconsistency and high-density ratio in a two-phase system for modeling the cavitation process. The three-dimensional shape of the microbubble during the collapse stages and the counter of pressure are displayed. There is a time difference between the occurrence of maximum velocity and pressure. All results in detail are presented in the article bodies.

中文翻译：

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受超声力影响的微泡-血细胞系统振荡/空化分析：FEM 和 LBM 的结合应用


声孔疗法是一种非侵入性方法，利用超声波进行药物和基因递送以达到治疗目的。在这里，有限元法（FEM）和格子玻尔兹曼法（LBM）都被应用于研究柔性组织附近微泡振荡和塌陷的相互作用物理。在用非线性激发脂质涂层微泡验证有限元法以及用实验结果验证格子玻尔兹曼法之后，我们研究了组织附近的三维可压缩微泡的行为。在 FEM 阶段，具有脂质壳的振荡微泡与边界相互作用。在声孔治疗应用领域中已经考虑了压力和超声频率的范围。研究了微泡壳涂层的粘弹性和界面张力。与自由微泡相比，弹性边界的存在增加了微泡的共振频率。压力的增加导致微泡运动范围、流体中引起的速度以及组织边界壁上的剪切应力的扩大。微泡表面张力的增强可以影响流体流动并降低边界上的剪切应力。多赝势相互作用 LBM 用于减少两相系统中的热力学不一致性和高密度比，以模拟空化过程。显示崩溃阶段微泡的三维形状和压力计数器。最大速度和压力的出现之间存在时间差。所有详细结果都在文章正文中给出。