Successful kilogram-scale preparation of the C27–C35 sulfide fragment of Eribulin was presented, which was elaborated with the C14–C26 fragment to produce a proprietary C14–C35 sulfide intermediate. The sulfide group was then oxidized to yield the known C14–C35 sulfone intermediate of Eribulin.

中文翻译：

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艾日布林 C27-C35 片段的专有合成及其对 C14-C35 亚基的精细化


成功地以公斤级制备了艾日布林的 C27-C35 硫化物片段，并与 C14-C26 片段进行了精心设计，产生了专有的 C14-C35 硫化物中间体。然后硫化物基团被氧化，生成已知的艾日布林 C14-C35 砜中间体。