An environmentally sustainable approach for the Hofmann rearrangement was developed. The presence of nanomicelles allows such a transformation to proceed smoothly in mild conditions with water as the sole reaction medium compared to traditional methods, which use significant amounts of organic solvents. A variety of amides containing functional groups have been constructed under these conditions, affording the compounding amine product in good to excellent yields (up to 99%). The process was scaled up and proven to be robust for its implementation in the synthesis of pharmaceutically relevant compounds.

中文翻译：

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水中胶束启用的霍夫曼重排


开发了一种环境可持续的霍夫曼重排方法。与使用大量有机溶剂的传统方法相比，纳米胶束的存在使得这种转化能够在温和的条件下顺利进行，以水作为唯一的反应介质。在这些条件下构建了多种含有官能团的酰胺，以良好至优异的收率（高达 99%）提供复合胺产品。该工艺已扩大规模，并被证明在药物相关化合物的合成中的实施是稳健的。