Radiosensitizers play a pivotal role in enhancing radiotherapy (RT). One of the challenges in RT is the limited accumulation of nanoradiosensitizers and the difficulty in activating antitumor immunity. Herein, a smart strategy was used to achieve in situ aggregation of nanomanganese adjuvants (MnAuNP-C&B) to enhance RT-induced antitumor immunity. The aggregated MnAuNP-C&B system overcomes the shortcomings of small-sized nanoparticles that easily flow back into blood vessels and diffuse into surrounding tissues, and it also prolongs the retention time of nanomanganese within cancer cells and tumors. The MnAuNP-C&B system significantly enhances the radiosensitization effect in RT. Additionally, the pH-responsive disassembly of MnAuNP-C&B triggers the release of Mn²⁺, further promoting RT-induced activation of the STING pathway and eliciting robust antitumor immunity. Overall, our study presents a smart strategy wherein in situ aggregation of nanomanganese effectively inhibits tumor growth through radiosensitization and the activation of antitumor immunity.

中文翻译：

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原位聚集的纳米锰增强辐射诱导的抗肿瘤免疫


放射增敏剂在增强放射治疗（RT）方面发挥着关键作用。 RT的挑战之一是纳米放射增敏剂的积累有限以及激活抗肿瘤免疫的困难。在此，采用智能策略实现纳米锰佐剂（MnAuNP-C&B）的原位聚集，以增强 RT 诱导的抗肿瘤免疫。聚集的MnAuNP-C&B系统克服了小尺寸纳米粒子容易流回血管并扩散到周围组织的缺点，并且还延长了纳米锰在癌细胞和肿瘤内的保留时间。 MnAuNP-C&B 系统显着增强 RT 中的放射增敏效果。此外，MnAuNP-C&B 的 pH 响应性分解会触发 Mn ²⁺ 的释放，进一步促进 RT 诱导的 STING 通路激活，并引发强大的抗肿瘤免疫。总的来说，我们的研究提出了一种明智的策略，其中纳米锰的原位聚集通过放射增敏和激活抗肿瘤免疫有效抑制肿瘤生长。