Organic dusts are mixtures of particles originating from plants, animals and often endotoxins from gram-negative bacteria. Several occupations, including farming (where exposures can occur during grain, animal handling and feeding), woodworking (where exposures can occur from wood dust) and textile work (during cotton processing), are the primary sources of occupational exposure to organic dust.1 2 Cross-sectional analysis has suggested a relationship between organic dust exposure and interstitial lung diseases (ILDs), specifically hypersensitivity pneumonitis (HP), mostly among farmers.3 HP, also known as extrinsic allergic alveolitis, is an immune-mediated disease triggered by the inhalation of organic dust, which contains antigens from bacteria, fungi, animal proteins and other sources.4 These antigens trigger an immune response in susceptible individuals, leading to the activation of alveolar macrophages and T-cells, releasing cytokines and chemokines, resulting in lung parenchyma inflammation and granuloma formation.5 The evidence for the association between organic dust exposure and HP is primarily from the case reports6 and workplace-based studies7 while the evidence from population-based studies using reliable data sources is largely missing. In this issue, Iversen et al investigated this association in a Danish population-based occupational cohort over three decades.8 The study examined data from a vast cohort of Danish residents born in 1956 or later who had been employed for at least a year …

中文翻译：

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揭示职业危害：探讨有机粉尘暴露与过敏性肺炎等间质性肺疾病的关系


有机粉尘是来自植物、动物的颗粒的混合物，通常还含有来自革兰氏阴性细菌的内毒素。多种职业，包括农业（谷物、动物处理和饲养过程中可能发生接触）、木工（木屑可能发生接触）和纺织工作（棉花加工过程中），是职业接触有机粉尘的主要来源。 1 2 横断面分析表明，有机粉尘接触与间质性肺病 (ILD)，特别是过敏性肺炎 (HP) 之间存在关系，主要发生在农民中。3 HP，也称为外源性过敏性肺泡炎，是一种免疫介导的疾病，由以下因素引发：吸入有机粉尘，其中含有来自细菌、真菌、动物蛋白和其他来源的抗原。4这些抗原会触发易感个体的免疫反应，导致肺泡巨噬细胞和 T 细胞激活，释放细胞因子和趋化因子，从而导致肺实质炎症和肉芽肿形成。5有机粉尘暴露与 HP 之间关联的证据主要来自病例报告6和基于工作场所的研究7，而使用可靠数据源的基于人群的研究的证据基本上缺失。在本期中，Iversen 等人在三十年来以丹麦人口为基础的职业队列中调查了这种关联。8 该研究检查了 1956 年或以后出生的大量丹麦居民的数据，这些居民已经工作了至少一年……