The asymmetric total syntheses of four pleurotin natural products, namely, (−)-pleurotin, (+)-leucopleurotin, (+)-leucopleurotinic acid, and (+)-dihydropleurotinic acid, were described in a concise manner. Key transformations feature a Johnson–Claisen rearrangement, a diastereo-controlled sequential hydroboration-oxidation, a SOMO/photoredox activated aldehyde α-alkylation, and oxidative cyclizations.

中文翻译：

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侧耳素天然产物的统一合成方法


简要描述了四种侧耳素天然产物，即(−)-侧耳素、(+)-无色侧耳素、(+)-无色侧耳素、(+)-无色侧耳素酸和(+)-二氢侧耳素酸的不对称全合成。关键转化包括 Johnson-Claisen 重排、非对映控制的连续硼氢化-氧化、SOMO/光氧化还原激活的醛 α-烷基化和氧化环化。