Directed hydrogen atom transfer to alkenes is described. The process is catalyzed by iron complexes and allows for the site-selective hydrofunctionalization of polyenols. Experimental data suggest that coordination of the hydroxy group to the iron hydride intermediate plays an important role in preferential engagement of the allylic alcohol motif and provides a new basis for selectivity in radical hydrofunctionalization events. As a proof of concept, β- and γ-amino alcohols are prepared from the corresponding polyenols in a selective manner.

中文翻译：

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用于多烯醇选择性反应的定向氢原子转移


描述了氢原子定向转移至烯烃。该过程由铁络合物催化，并允许多烯醇进行位点选择性氢官能化。实验数据表明，羟基与氢化铁中间体的配位在烯丙醇基序的优先接合中起着重要作用，并为自由基氢官能化事件的选择性提供了新的基础。作为概念证明，β-和γ-氨基醇是由相应的多烯醇以选择性方式制备的。