Sulfinamides have been widely used in organic synthesis, with research on their preparation spanning more than a century. Despite advancements in catalytic methodologies, creating sulfur stereocenters within these molecules remains a significant challenge. In this study, we present an effective and versatile method for synthesizing a diverse range of S-chirogenic sulfinamides through catalytic asymmetric aryl addition to sulfinylamines. By utilizing a nickel complex as a catalyst, this process exhibits impressive enantioselectivity and can incorporate various arylboronic acids at the sulfur position. The resulting synthetic sulfinamides are stable and highly adaptable, allowing for their conversion to a variety of sulfur-containing compounds. Our study also incorporates detailed experimental and computational studies to elucidate the reaction mechanism and factors influencing enantioselectivity.

中文翻译：

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镍催化下亚磺胺与芳基硼酸的不对称 2,3-加成


亚磺酰胺已广泛应用于有机合成中，对其制备的研究已有一个多世纪的历史。尽管催化方法取得了进步，但在这些分子内创建硫立构中心仍然是一个重大挑战。在这项研究中，我们提出了一种有效且通用的方法，通过催化不对称芳基加成到亚磺胺上来合成各种 S-手性亚磺酰胺。通过利用镍络合物作为催化剂，该过程表现出令人印象深刻的对映选择性，并且可以在硫位置结合各种芳基硼酸。所得的合成亚磺酰胺稳定且适应性强，可以转化为多种含硫化合物。我们的研究还结合了详细的实验和计算研究，以阐明反应机理和影响对映选择性的因素。