Probiotics are indispensable for maintaining the structure of gut microbiota and promoting human health, yet their survivability is frequently compromised by environmental stressors such as temperature fluctuations, pH variations, and mechanical agitation. In response to these challenges, microfluidic technology emerges as a promising avenue. This comprehensive review delves into the utilization of microfluidic technology for the encapsulation and delivery of probiotics within the gastrointestinal tract, with a focus on mitigating obstacles associated with probiotic viability. Initially, it elucidates the design and application of microfluidic devices, providing a precise platform for probiotic encapsulation. Moreover, it scrutinizes the utilization of carriers fabricated through microfluidic devices, including emulsions, microspheres, gels, and nanofibers, with the intent of bolstering probiotic stability. Subsequently, the review assesses the efficacy of encapsulation methodologies through in vitro gastrointestinal simulations and in vivo experimentation, underscoring the potential of microfluidic technology in amplifying probiotic delivery efficiency and health outcomes. In sum, microfluidic technology represents a pioneering approach to probiotic stabilization, offering avenues to cater to consumer preferences for a diverse array of functional food options.

中文翻译：

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用于益生菌封装、保护和控制递送的微流体策略


益生菌对于维持肠道菌群结构和促进人类健康不可或缺，但它们的生存能力经常受到温度波动、pH 值变化和机械搅拌等环境压力因素的影响。为了应对这些挑战，微流体技术成为一种有前途的途径。这篇全面的综述深入探讨了微流体技术在胃肠道内封装和输送益生菌的应用，重点是减轻与益生菌活力相关的障碍。首先，它阐明了微流体装置的设计和应用，为益生菌封装提供了精确的平台。此外，它还仔细检查了通过微流体装置制造的载体的利用，包括乳液、微球、凝胶和纳米纤维，以增强益生菌的稳定性。随后，该综述通过体外胃肠模拟和体内实验评估了封装方法的功效，强调了微流体技术在提高益生菌递送效率和健康结果方面的潜力。总之，微流体技术代表了益生菌稳定性的开创性方法，为满足消费者对各种功能性食品选择的偏好提供了途径。