While existing polyoxometalates (POMs) are predominantly utilized in a range of energy devices, their potential in bioelectronics and optoelectronics, particularly in organic photoelectrochemical transistors (OPECTs), remains unexplored. Here, the potential of POMs in this aspect is unveiled by a POM/sulfide‐gated OPECT. The representative PW12/ZnIn2S4 with cascading light‐harvesting and enzyme‐like functionality enables unique on‐off OPECT operation. The incorporation of PW12 facilitates the separation of photogenerated charge carriers across the heterojunction interface, consequently inducing a pronounced gating effect. Linking with a CRISPR/Cas13a system correlating the target miRNA‐21 and biological generation of H2O2, the PW12 will enable the polymerization of dopamine into polydopamine and thus sensitively inhibit the OPECT gating. Experimental results demonstrated that the developed OPECT sensor achieved good analytical performance with a detection limit as low as 3.9 fm. This study demonstrates the potential of POMs in OPECT. Given the large family and multifunction of POMs, its implications in the diverse bioelectronics and optoelectronics are expected.

中文翻译：

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多金属氧酸盐：独特的开关有机光电化学晶体管操作的级联功能


虽然现有的多金属氧酸盐（POM）主要用于一系列能源设备，但它们在生物电子学和光电子学，特别是有机光电化学晶体管（OPECT）中的潜力仍未得到开发。在这里，POM/硫化物门控 OPECT 揭示了 POM 在这方面的潜力。代表性的 PW12/ZnIn2S4 具有级联光捕获和类酶功能，可实现独特的开关 OPECT 操作。 PW12 的加入有利于光生电荷载流子在异质结界面上的分离，从而产生明显的门控效应。 PW12 与将目标 miRNA-21 和 H2O2 的生物生成相关联的 CRISPR/Cas13a 系统连接，将使多巴胺聚合成聚多巴胺，从而敏感地抑制 OPECT 门控。实验结果表明，所开发的 OPECT 传感器具有良好的分析性能，检测限低至 3.9 fm。这项研究证明了 POM 在 OPECT 中的潜力。鉴于 POM 的大家族和多功能性，其对多种生物电子学和光电子学的影响是值得期待的。