The study of nano‐biointeractions, at the forefront of interdisciplinary research, unveils intricate interplays between nanomaterials (NMs) and intracellular organelles, which are pivotal hubs orchestrating diverse cellular processes. Thanks also to the formation of dynamic contacts among their membranes, organelles regulate lipid exchange, calcium signaling, and metabolic pathways. Recently, the potential role of NMs in cellular homeostasis through the regulation of organelle membrane contact sites (MCSs) is emerging, and a complete overview of this issue is still lacking. This perspective aims at elucidating the synergy between functional NMs and organelle contact site research, underscoring the pivotal role of NMs in advancing the comprehension of cell biology mechanisms and fostering therapeutic breakthroughs. This subject represents a crucial aspect of nano‐biointeractions, as it can reveal new molecular targets for NMs and potentially revolutionize therapeutic strategies. Nanotechnology may offer unprecedented tools to decipher and manipulate dynamic organelle interfaces with remarkable precision. Engineered nanomaterials may serve as versatile probes and effectors, enabling targeted modulation of organelle contact sites and unraveling the molecular intricacies governing organelle dynamics. Furthermore, nano‐biointeraction‐driven insights hold promise for therapeutic innovations, offering novel avenues in diseases linked to dysregulated organelle contacts.

中文翻译：

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功能纳米材料的纳米生物相互作用：细胞器间接触位点、靶向和信号传导的新兴作用


纳米生物相互作用的研究处于跨学科研究的前沿，揭示了纳米材料（NM）和细胞内细胞器之间复杂的相互作用，细胞器是协调不同细胞过程的关键枢纽。由于膜之间动态接触的形成，细胞器可以调节脂质交换、钙信号传导和代谢途径。最近，NM 通过调节细胞器膜接触位点 (MCS) 在细胞稳态中的潜在作用正在显现，但仍然缺乏对该问题的完整概述。这一观点旨在阐明功能性 NM 和细胞器接触位点研究之间的协同作用，强调 NM 在促进对细胞生物学机制的理解和促进治疗突破方面的关键作用。该主题代表了纳米生物相互作用的一个重要方面，因为它可以揭示纳米生物的新分子靶标，并有可能彻底改变治疗策略。纳米技术可以提供前所未有的工具来以惊人的精度破译和操纵动态细胞器界面。工程纳米材料可以用作多功能探针和效应器，能够有针对性地调节细胞器接触位点，并揭示控制细胞器动力学的分子复杂性。此外，纳米生物相互作用驱动的见解有望实现治疗创新，为与细胞器接触失调相关的疾病提供新的途径。