Little is known regarding the association between chronic tonsillitis and the onset of IgA nephropathy (IgAN). In the present study, we examined the potential relationship between chronic tonsillitis and a subsequent risk of developing IgAN. Observational cohort study. & Participants: 4,311,393 individuals without a history of IgAN identified between January 2005 to May 2022 within a Japanese nationwide epidemiological database, the JMDC Claims Database, representing health claims to over 60 insurers. Comorbid chronic tonsillitis based on diagnosis codes. IgAN occurrence. Cause-specific Cox proportional hazards analysis adjusting for potential confounding factors were employed to estimate hazard ratios (HRs). Comorbid chronic tonsillitis was identified in 12,842 individuals, constituting 0.3% of the cohort. The cohort had a median age of 44 years (interquartile range: 36-53), and males accounted for 57.9%, with a follow-up of 1,089 days (interquartile range: 532-1,797), during which 2,653 cases of IgAN developed. Cumulative incidence curve showed a higher cumulative incidence of IgAN in individuals with chronic tonsillitis compared to their counterparts without this condition. Multivariable cause-specific analysis further demonstrated that individuals with chronic tonsillitis had an elevated risk of developing IgAN, with a HR of 2.72 (95% confidence interval: 1.79-4.14). Potential residual confounders, and lack of consideration for ethnic distinctions. Using a largescale epidemiological dataset, these findings suggest a relationship between chronic tonsillitis and an elevated risk of IgAN development in the general Japanese population.

中文翻译：

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慢性扁桃体炎和 IgA 肾病：日本全国队列研究的结果


关于慢性扁桃体炎和 IgA 肾病 (IgAN) 发病之间的关系知之甚少。在本研究中，我们研究了慢性扁桃体炎与随后发生 IgAN 的风险之间的潜在关系。观察性队列研究。 & 参与者：2005 年 1 月至 2022 年 5 月期间，日本全国流行病学数据库 JMDC 索赔数据库中发现了 4,311,393 名没有 IgAN 病史的个体，代表了 60 多家保险公司的健康索赔。基于诊断代码的共病慢性扁桃体炎。 IgAN 的发生。采用针对潜在混杂因素进行调整的特定原因 Cox 比例风险分析来估计风险比 (HR)。在 12,842 人中发现了共病慢性扁桃体炎，占该队列的 0.3%。该队列的中位年龄为 44 岁（四分位距：36-53），男性占 57.9%，随访时间为 1,089 天（四分位距：532-1,797），期间有 2,653 例 IgAN 发生。累积发病率曲线显示，与没有慢性扁桃体炎的患者相比，慢性扁桃体炎患者的 IgAN 累积发病率更高。多变量特定原因分析进一步表明，患有慢性扁桃体炎的个体患 IgAN 的风险较高，HR 为 2.72（95% 置信区间：1.79-4.14）。潜在的残留混杂因素，以及缺乏对种族差异的考虑。使用大规模流行病学数据集，这些发现表明日本普通人群中慢性扁桃体炎与 IgAN 发生风险升高之间存在关系。