Silicon dioxide nanoparticles induce anxiety-like behavior in a size-specific manner via the microbiota-gut-brain axis,Environmental Toxicology and Pharmacology

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Silicon dioxide nanoparticles induce anxiety-like behavior in a size-specific manner via the microbiota-gut-brain axis
Environmental Toxicology and Pharmacology ( IF 4.2 ) Pub Date : 2024-06-21 , DOI: 10.1016/j.etap.2024.104493
Kaiyan Gong ₁ , Xiaoli Yin ₂ , Jiahui Lu ₂ , Hong Zheng ₂ , Wenjun Wu ₃

Affiliation

The impacts of silicon dioxide nanoparticles (SiO-NPs) on human health have attracted increasing interest due to their widespread utilization in medicine and food additives. However, the size-dependent effects of SiO-NPs on brain health remain sparse. Herein we investigated alterations in behavioral patterns, the gut microbiota, inflammation and oxidative stress of mice after a 12-week exposure to SiO-NPs with either small size (NP-S) or large size (NP-L). A more pronounced deleterious effect of NP-S was found on anxiety-like behavior in mice relative to NP-L. We also found that SiO-NPs exposure induced inflammation and oxidative stress in the colon, hippocampus and cortex of mice in a size-specific manner. Correlation network analysis revealed potential links between anxiety-like behavior and SiO-NPs-induced shifts in the gut microbiota including , , and . Furthermore, anxiety-like behavior caused by SiO-NPs exposure exhibited correlations with decreased levels of hippocampal IL-10 and cortex Nqo1 as well as increased levels of intestinal Acox1 and hippocampal TNF-α. Therefore, our findings suggest that exposure to SiO-NPs promoted anxiety-like behavior through the mediation of interplay between the gut and the brain, and SiO-NPs of smaller size may generate a more adverse effect on brain health.

中文翻译：

二氧化硅纳米粒子通过微生物群-肠-脑轴以特定尺寸的方式诱导焦虑样行为

二氧化硅纳米粒子（SiO-NPs）由于其在医药和食品添加剂中的广泛应用，对人类健康的影响引起了越来越多的关注。然而，SiO-NPs 对大脑健康的尺寸依赖性影响仍然很少。在此，我们研究了小鼠接触小尺寸 (NP-S) 或大尺寸 (NP-L) SiO-NP 12 周后行为模式、肠道微生物群、炎症和氧化应激的变化。相对于 NP-L，NP-S 对小鼠的焦虑样行为有更明显的有害影响。我们还发现，SiO-NPs 暴露以特定大小的方式诱导小鼠结肠、海马和皮质的炎症和氧化应激。相关网络分析揭示了焦虑样行为与 SiO-NPs 诱导的肠道微生物群变化之间的潜在联系，包括、、和。此外，SiO-NPs 暴露引起的焦虑样行为与海马 IL-10 和皮质 Nqo1 水平降低以及肠道 Acox1 和海马 TNF-α 水平升高相关。因此，我们的研究结果表明，接触 SiO-NPs 通过调节肠道和大脑之间的相互作用促进了焦虑样行为，并且较小尺寸的 SiO-NPs 可能对大脑健康产生更不利的影响。

更新日期：2024-06-21

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