A molecularly imprinting polymer (MIP) carrier with pH-responsivity was designed to construct a drug delivery system (DDS) focusing on controlled and sustainable capecitabine (CAPE) release. The pH-responsive characteristic was achieved by the functionalization of SiO substrate with 4-formylphenylboronic acid, accompanied by the introduction of fluorescein isothiocyanate for the visualization of the intracellular localization of the nanocarrier. Experimental results indicated that CAPE was adsorbed onto the drug carrier with satisfactory encapsulation efficiency. The controlled release of CAPE was realized based on the break of borate ester bonds between -B(OH) and -diols in the weakly acidic environment. Density functional theory computations were conducted to investigate the adsorption/release mechanism. Moreover, experiments confirmed the good biocompatibility and ideal inhibition efficiency of the developed DDS. The MIP can act as an eligible carrier and exhibits the great potential in practical applications for tumor treatment.

中文翻译：

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pH响应性分子印迹聚合物作为卡培他滨可控和可持续释放载体的设计


设计了一种具有 pH 响应性的分子印迹聚合物 (MIP) 载体，用于构建专注于受控和可持续卡培他滨 (CAPE) 释放的药物递送系统 (DDS)。 pH 响应特性是通过用 4-甲酰基苯基硼酸对 SiO 基底进行功能化来实现的，同时引入异硫氰酸荧光素以可视化纳米载体的细胞内定位。实验结果表明CAPE以良好的包封率吸附在药物载体上。 CAPE的控释是基于弱酸性环境中-B(OH)和-二醇之间硼酸酯键的断裂实现的。进行密度泛函理论计算来研究吸附/释放机制。此外，实验证实所开发的DDS具有良好的生物相容性和理想的抑制效率。 MIP可以作为合格的载体，在肿瘤治疗的实际应用中展现出巨大的潜力。