Aromatic amino acids (AAA) and derived compounds have enormous commercial value with extensive applications in the food, chemical and pharmaceutical fields. Microbial production of AAA and derived compounds is a promising prospect for its environmental friendliness and sustainability. However, low yield and production efficiency remain major challenges for realizing industrial production. With the advancement of synthetic biology, microbial production of AAA and derived compounds has been significantly facilitated. In this review, a comprehensive overview on the current progresses, challenges and corresponding solutions for AAA and derived compounds biosynthesis is provided. The most cutting-edge developments of synthetic biology technology in AAA and derived compounds biosynthesis, including CRISPR-based system, genetically encoded biosensors and synthetic genetic circuits, were highlighted. Finally, future prospects of modern strategies conducive to the biosynthesis of AAA and derived compounds are discussed. This review offers guidance on constructing microbial cell factory for aromatic compound using synthetic biology technology.

中文翻译：

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现代合成生物学技术在芳香氨基酸及其衍生化合物生物合成中的应用


芳香氨基酸（AAA）及其衍生化合物具有巨大的商业价值，在食品、化工和制药领域有着广泛的应用。 AAA及其衍生化合物的微生物生产因其环境友好性和可持续性而具有广阔的前景。然而，低产量和生产效率仍然是实现工业化生产的主要挑战。随着合成生物学的进步，AAA及其衍生化合物的微生物生产已得到显着促进。在这篇综述中，全面概述了 AAA 及其衍生化合物生物合成的当前进展、挑战和相应的解决方案。重点介绍了AAA及其衍生化合物生物合成领域合成生物学技术的最前沿进展，包括基于CRISPR的系统、基因编码生物传感器和合成基因电路。最后，讨论了有利于 AAA 及其衍生化合物生物合成的现代策略的未来前景。该综述为利用合成生物学技术构建芳香族化合物微生物细胞工厂提供了指导。