Short-Term Postnatal Overfeeding Induces Long-Lasting Cardiometabolic Syndrome in Mature and Old Mice Associated with Increased Sensitivity to Myocardial Infarction,Molecular Nutrition & Food Research

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Short-Term Postnatal Overfeeding Induces Long-Lasting Cardiometabolic Syndrome in Mature and Old Mice Associated with Increased Sensitivity to Myocardial Infarction
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-06-27 , DOI: 10.1002/mnfr.202400136
Eve Rigal ₁ , Marie Josse ₁ , Camille Greco ₁ , Nathalie Rosenblatt ₂ , Luc Rochette ₁ , Charles Guenancia _{1,

3} , Catherine Vergely ₁

Affiliation

Perinatal nutritional disturbances may “program” an increased cardio-metabolic risk in adulthood; however, few experimental studies have explored their effects on mature and/or old animal. This study aims to investigate the influence of postnatal overfeeding (PNOF) on cardiac function, sensitivity to ischemia-reperfusion (I-R) injury in vivo, glucose metabolism, and metabolic profile of pericardial adipose tissue (PAT) in young (4 months), adult (6 months), old (12 months), and very old (18 months) male mice.

中文翻译：

产后短期过度喂养会导致成熟和老年小鼠出现长期的心脏代谢综合征，并与心肌梗塞的敏感性增加相关

围产期营养失调可能会“编程”成年后心脏代谢风险的增加；然而，很少有实验研究探讨它们对成熟和/或老年动物的影响。本研究旨在探讨产后过度喂养（PNOF）对年轻（4个月）和成人的心脏功能、体内缺血再灌注（IR）损伤敏感性、葡萄糖代谢和心包脂肪组织（PAT）代谢特征的影响（6 个月）、老年（12 个月）和非常老（18 个月）雄性小鼠。

更新日期：2024-06-27

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