Postbiotics Prepared Using Lactobacillus reuteri Ameliorates Ethanol-Induced Liver Injury by Regulating the FXR/SHP/SREBP-1c Axis,Molecular Nutrition & Food Research

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Postbiotics Prepared Using Lactobacillus reuteri Ameliorates Ethanol-Induced Liver Injury by Regulating the FXR/SHP/SREBP-1c Axis
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-06-27 , DOI: 10.1002/mnfr.202300927
Chen Liu _{1,

2} , Tianying Cai ₃ , Yonglang Cheng ₄ , Junjie Bai _{1,

2} , Mo Li _{1,

2} , Boyuan Gu _{1,

2} , Meizhou Huang _{1,

2} , Wenguang Fu _{1,

2}

Affiliation

While probiotics-based therapies have exhibited potential in alleviating alcohol-associated liver disease (ALD), the specific role of postbiotics derived from Lactobacillus reuteri (L. reuteri) in ALD remains elusive. This study aims to investigate the impact of postbiotics on ameliorating alcohol-induced hepatic steatosis and the underlying mechanisms.

中文翻译：

使用罗伊氏乳杆菌制备的后生元通过调节 FXR/SHP/SREBP-1c 轴改善乙醇引起的肝损伤

虽然基于益生菌的疗法在缓解酒精相关性肝病 (ALD) 方面表现出潜力，但源自罗伊氏乳杆菌( L. reuteri ) 的后生元在 ALD 中的具体作用仍然难以捉摸。本研究旨在探讨后生元对改善酒精性肝脂肪变性的影响及其潜在机制。

更新日期：2024-06-27

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