Iodine Mediated Annulation of Triethylamine, Aldehydes and 2-Aminopyridines for the Synthesis of 3-Formyl-Imidazo [1,2-a]pyridine Derivatives,Advanced Synthesis & Catalysis

当前位置： X-MOL 学术 › Adv. Synth. Catal. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Iodine Mediated Annulation of Triethylamine, Aldehydes and 2-Aminopyridines for the Synthesis of 3-Formyl-Imidazo [1,2-a]pyridine Derivatives
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2024-06-27 , DOI: 10.1002/adsc.202400473
Wenqing Zhang ₁ , Lihong Shen ₂ , Jun Zhang ₁

Affiliation

With triethylamine as a synthon, an alternative method for the synthesis of 3-formyl imidazo[1,2-a]pyridines has been accomplished from aldehydes, and 2-aminopyridines. The reaction proceeded via iodine-catalyzed C−N bond cleavage of triethylamine, generation of α,β-unsaturated aldehyde in situ, and oxidative cyclization with air as the oxygen source. This protocol may facilitate the synthesis of imidazo[1,2-a]pyridine derivatives and provide a reference for the usage of triethylamine as a synthon.

中文翻译：