A mild and efficient electrochemical method for radical addition, cyclization, and migration reaction was described in this work. A difluoromethyl radical was produced by anodizing CF₂HSO₂Na. The resulting product was then added to olefin, underwent Smiles cyclization, and migrated to form β-difluoromethamide compounds after the release of SO₂. The process was free from metals and catalysts, gram-grade, and resistant to a variety of electron-rich substrates.

中文翻译：

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N-苯磺酰丙烯酰胺与二氟试剂电化学合成β-二氟甲酰胺类化合物


这项工作描述了一种温和有效的自由基加成、环化和迁移反应的电化学方法。通过阳极氧化 CF ₂ HSO ₂ Na 产生二氟甲基自由基。然后将所得产物加入到烯烃中，进行Smiles环化，并在释放SO ₂ 后迁移形成β-二氟甲酰胺化合物。该工艺不含金属和催化剂，是克级的，并且对各种富电子底物具有耐受性。