Alleviation of Menopausal Symptoms by Yam (Dioscorea japonica Thunb.) and Gromwell (Lithospermum erythrorhizon Sieb. Et Zucc.) Extracts in Ovariectomized Mice,Molecular Nutrition & Food Research

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Alleviation of Menopausal Symptoms by Yam (Dioscorea japonica Thunb.) and Gromwell (Lithospermum erythrorhizon Sieb. Et Zucc.) Extracts in Ovariectomized Mice
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-06-27 , DOI: 10.1002/mnfr.202400158
Hyejeong Park ₁ , Hyunju Ha ₁ , Hyeji Lee ₁ , Gyeongwhan Lee ₁ , Gwang-Woong Go ₂ , Tae Mi Yoon ₃ , Tae Yeol Kim ₃ , Wooki Kim ₄

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The decline in estrogen during menopause contributes to a variety of menopausal symptoms, for which hormone replacement therapy (HRT) has been extensively applied. Regarding side effects and limited effectiveness of HRT for specific individuals, there is a growing interest in safe alternatives such as phytoestrogens which are structurally analogous to estrogens. This study aims to investigate the efficacy of yam and gromwell extracts, rich in bioactive compounds, and the synergistic effect of extracts on symptoms induced by estrogen deficiency in ovariectomized (OVX) mice.

中文翻译：

山药 (Dioscorea japonica Thunb.) 和紫草 (Lithospermum erythrorhizon Sieb. Et Zucc.) 提取物对卵巢切除小鼠的更年期症状的缓解作用

更年期雌激素下降导致多种更年期症状，激素替代疗法（HRT）已被广泛应用。关于激素替代疗法对特定个体的副作用和有限有效性，人们对安全替代品越来越感兴趣，例如结构上与雌激素类似的植物雌激素。本研究旨在研究富含生物活性化合物的山药和紫草提取物的功效，以及提取物对卵巢切除（OVX）小鼠雌激素缺乏引起的症状的协同作用。

更新日期：2024-06-27

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